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Product Name | Zofenoprilat |
Description | An ACE inhibitor (IC50 = 8 nM for the rabbit lung enzyme) and active metabolite of zofenopril; inhibits angiotensin I- or bradykinin-induced contractions of isolated guinea pig ileum (EC50s = 3 and 1 nM, respectively); decreases basal endothelin-1 secretion and NO production, as well as prevents TNF-α-induced increases in ROS and decreases GSH levels, in HUVECs at 10 nM; protects primary human cardiac microvascular endothelial cells against doxorubicin-induced cytotoxicity at 10 µM; increases H2S production in, and adhesion, migration, and proliferation of, HUVECs at 10 µM; reduces end diastolic pressure and LDH release in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury at 400 µM |
Size | 500 µg |
Concentration | n/a |
Applications | n/a |
Other Names | SQ 26,333|Zofenopril-SH |
Gene, Accession, CAS # | CAS: 75176-37-3 |
Catalog # | 38124-500 |
Price | $101.00 |
Order / More Info | Zofenoprilat from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |