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Product Name | A-839977 |
Description | A P2X7 receptor antagonist; inhibits BzATP-evoked intracellular calcium influx in 1321N1 cells expressing human, rat, and mouse receptors (IC50s = 20, 42, and 150 nM, respectively); inhibits BzATP-induced YO-PRO dye uptake and IL-1β release from THP-1 cells (IC50s = 6.6 and 37 nM, respectively); reduces thermal hyperalgesia in rats at 30, 100, and 300 µmol/kg, i.p.; reduces thermal and mechanical hyperalgesia in a rat MRMT-1 mammary carcinoma model of cancer-induced bone pain at 40 mg/kg |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | A839977 P2X 7 Bz-ATP 1321N-1 Ca YOPRO IL-1β interleukin 1 β THP1 MRMT1 |
Gene, Accession, CAS # | CAS: 870061-27-1 |
Catalog # | 30934-5 |
Price | $116.00 |
Order / More Info | A-839977 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |