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Product Name | AB-680 |
Description | An inhibitor of ecto-5'-nucleotidase (IC50 = 0.043 nM in CHO cells expressing the human enzyme); selective for ecto-5'-nucleotidase over NTPDase 1, NTPDase 2, NTPDase 3, and NTPDase 8 (IC50s = >10 µM for all); inhibits ecto-5'-nucleotidase activity in isolated human and mouse CD8+ T cells and isolated human PBMCs (IC50s = 0.008, 0.66, and 0.011 nM, respectively); reverses AMP-induced decreases in the proliferation of, and IFN-γ and granzyme B secretion by, isolated human CD4+ and CD8+ T cells at 200 nM; reduces tumor volume in a B16/F10 murine melanoma model alone and in combination with an anti-PD-1 antibody |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | Quemliclustat |
Gene, Accession, CAS # | CAS: 2105904-82-1 |
Catalog # | 32798-25 |
Price | $861.00 |
Order / More Info | AB-680 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |