Voclosporin from CAYMAN CHEMICAL COMPANY
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| Product Name | Voclosporin |
| Description | An immunosuppressant; binds to cyclophilin A (Kd = 15 nM); inhibits calcineurin activity in isolated human whole blood (IC50 = 120 ng/ml); reduces the proliferation of, and production of IL-2, IFN-γ, and TNF-α in, isolated cynomolgus monkey lymphocytes (EC50s = 202.79, 135.32, 177.11, and 138.56 ng/ml, respectively); decreases disease severity in a rat model of IRBP-induced experimental autoimmune uveoretinitis from 2.5-40 mg/kg; increases graft survival in a rat model of heterotopic heart transplantation at 1.75 mg/kg; unlike cyclosporin A, it does not increase serum creatinine levels in rabbits; inhibits the replication of SARS-CoV-2 in infected Calu-3 cells |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | (E)-ISA247|trans-ISA 247|ISATX247|LX211|R-15424 |
| Gene, Accession, CAS # | CAS: 515814-01-4 |
| Catalog # | 39719-10 |
| Price | $968.00 |
| Order / More Info | Voclosporin from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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