LNP023 (hydrochloride) from CAYMAN CHEMICAL COMPANY
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| Product Name | LNP023 (hydrochloride) |
| Description | A CFB inhibitor (IC50 = 10 nM); selective for CFB over a panel of 41 human proteases and 110 other enzymes, receptors, and ion channels (IC50s = >30 µM for all); inhibits zymosan A-induced formation of the membrane attack complex in isolated human blood (IC50 = 150 nM); blocks hemolysis of erythrocytes isolated from patients with paroxysmal nocturnal hemoglobinuria (IC50 = 400 nM); reduces levels of complement factor Ba, -C3d, and -C5a in the joints, levels of inflammatory cell infiltration in joint tissue, and arthritis disease severity in a K/BxN serum transfer-induced mouse model of inflammatory arthritis at 60 mg/kg twice per day; decreases proteinuria and serum levels of urea and creatine and prevents hair loss and kidney damage in an MRL-lpr mouse model of lupus nephritis at 30 mg/kg per day |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | Ipatacopan |
| Gene, Accession, CAS # | CAS: 1646321-63-2 |
| Catalog # | 37291-10 |
| Price | $484.00 |
| Order / More Info | LNP023 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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