A-839977 from CAYMAN CHEMICAL COMPANY
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| Product Name | A-839977 |
| Description | A P2X7 receptor antagonist; inhibits BzATP-evoked intracellular calcium influx in 1321N1 cells expressing human, rat, and mouse receptors (IC50s = 20, 42, and 150 nM, respectively); inhibits BzATP-induced YO-PRO dye uptake and IL-1β release from THP-1 cells (IC50s = 6.6 and 37 nM, respectively); reduces thermal hyperalgesia in rats at 30, 100, and 300 µmol/kg, i.p.; reduces thermal and mechanical hyperalgesia in a rat MRMT-1 mammary carcinoma model of cancer-induced bone pain at 40 mg/kg |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | A839977 P2X 7 Bz-ATP 1321N-1 Ca YOPRO IL-1β interleukin 1 β THP1 MRMT1 |
| Gene, Accession, CAS # | CAS: 870061-27-1 |
| Catalog # | 30934-1 |
| Price | $32.00 |
| Order / More Info | A-839977 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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