cGAS TR-FRET Inhibitor Screening Assay Kit from CAYMAN CHEMICAL COMPANY
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| Product Name | cGAS TR-FRET Inhibitor Screening Assay Kit |
| Description | Cayman's cGAS TR-FRET Inhibitor Screening Assay Kit provides a robust and easy-to-use time-resolved Foerster resonance energy transfer (TR-FRET) platform for identifying novel inhibitors of human cGAS, which is a cystosolic dsDNA sensor that detects microbial pathogens. This assay utilizes a mouse anti-rabbit monoclonal immunoglobulin G (IgG) directly labeled with a europium (Eu3+) chelate as a donor molecule and fluorescently labeled 2'3'-cGAMP as the acceptor molecule. In the presence of an anti-2'3'-cGAMP antibody, the donor and acceptor are brought into close proximity resulting in a FRET from the donor to the acceptor upon excitation of the Eu3+-conjugated IgG at 340 nm and an emission from the acceptor at 665 nm. In the assay, production of 2'3'-cGAMP by cGAS in the presence of dsDNA, ATP, and GTP results in the displacement of fluorescently labeled 2'3'-cGAMP from the anti-2'3'-cGAMP antibody, resulting in a loss of TR-FRET signal. Inhibition of cGAS maintains the signal. The cGAS inhibitor CU-76 is included as a positive control. |
| Size | 96 Well |
| Concentration | n/a |
| Applications | TR-FRET |
| Other Names | 2'3'-cGAMP Synthase|C6orf150|Cyclic GMP-AMP Synthase |
| Gene, Accession, CAS # | n/a |
| Catalog # | 702120-96WELLS |
| Price | $671.00 |
| Order / More Info | cGAS TR-FRET Inhibitor Screening Assay Kit from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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