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Product Name | A-784168 |
Description | A TRPV1 competitive antagonist; inhibits capsaicin-induced activation of TRPV1 in 1321N1 cells expressing TRPV1 (IC50 = 25 nM for the human receptor); selective for TRPV1 over a panel of 74 neurotransmitter receptors, ion channels, and other TRP channels at 50 µM but does act as an antagonist at TRPM8 (IC50 = 20.8 µM); inhibits TRPV1 activation induced by mildly acidic conditions, NADA, or anandamide in HEK293 cells (IC50s = 14, 33.7, and 35.1 nM, respectively); inhibits capsaicin-induced currents in primary rat dorsal root ganglion neurons (IC50 = 10 nM); inhibits NGF-induced thermal hypersensitivity and mechanical hypersensitivity in rats at 200 µmol/kg |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | A784168 TRPV 1 TRPM 8 HEK 293 |
Gene, Accession, CAS # | CAS: 824982-41-4 |
Catalog # | 32855-25 |
Price | $533.00 |
Order / More Info | A-784168 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |