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Product Name | K777 |
Description | A cysteine protease inhibitor; inhibits human cathepsin S and cathepsin L (Kis = 0.002 and 0.05 µM) and is selective for these proteases over human cathepsin K, -B, and -C (Kis = 0.4, 3, >100 µM, respectively), as well as SARS-CoV-2 PLpro and Mpro (Kis = >100 µM for both); prevents cleavage of the spike protein S1 subunit in vitro and reduces the cytopathic effect of SARS-CoV-2 in infected Vero E6, HeLa/ACE2, and A549/ACE2 cells (EC50s = T. b. brucei trypanosomes (IC50 = 0.1 µM) and reduces myocardial damage in a canine model of T. cruzi infection at 50 mg/kg twice per day; inhibits CCL17 binding to, and CCL17-induced chemotaxis of, HuT 78 cells (IC50s = 0.057 and 0.0089 µM, respectively) |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | ?APC-3316|CRA-3316|K11777|MePip-Phe-hPhe-VSφ |
Gene, Accession, CAS # | CAS: 233277-99-1 |
Catalog # | 19114-5 |
Price | $202.00 |
Order / More Info | K777 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |