ABBV-CLS-484 (hydrochloride) from CAYMAN CHEMICAL COMPANY
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| Product Name | ABBV-CLS-484 (hydrochloride) |
| Description | An inhibitor of PTP1N and PTP2N (IC50s = 2.5 and 1.8 nM, respectively); selective for PTP1N and PTP2N over PTP6N and PTP11N (IC50s = >10 µM for both) but does inhibit PTP9N (IC50 = 15 nM); potentiates IFN-γ-induced decreases in the proliferation of B16-F1 cancer cells at 1 µM; reduces tumor volume in combination with an anti-PD-L1 antibody in a B16-F1 melanoma murine model at 20 mg/kg per day; increases the number of CD8+ effector T cells, NK T cells, neutrophils, and monocytes expressing high levels of IFN-γ-induced genes, as well as increases M1 and decreases M2 macrophages, in the same mouse model a 20 mg/kg per day |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | Osunprotafib |
| Gene, Accession, CAS # | n/a |
| Catalog # | 40169-1 |
| Price | $499.00 |
| Order / More Info | ABBV-CLS-484 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY